Software Open Access
ECGSYN  A realistic ECG waveform generator
Published: Dec. 3, 2003. Version: 1.0.0
ECGSYN: A realistic ECG waveform generator (Dec. 3, 2003, midnight)
Patrick McSharry and Gari Clifford have contributed ECGSYN, software for generating a realistic ECG signal with a wide variety of usersettable parameters. The package includes C, Java, and Matlab/Octave implementations, together with a paper describing the model.
McSharry PE, Clifford GD, Tarassenko L, Smith L. A dynamical model for generating synthetic electrocardiogram signals. IEEE Transactions on Biomedical Engineering 50(3): 289294; March 2003.
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Goldberger, A., Amaral, L., Glass, L., Hausdorff, J., Ivanov, P. C., Mark, R., ... & Stanley, H. E. (2000). PhysioBank, PhysioToolkit, and PhysioNet: Components of a new research resource for complex physiologic signals. Circulation [Online]. 101 (23), pp. e215–e220.
Abstract
ECGSYN is a collection of software packages for generating realistic ECG waveforms. A number of settable parameters are available, including mean heart rate, number of beats, sampling frequency, waveform morphology, standard deviation of the RR interval, and LF/HF ratio (a measure of the relative contributions of the low and high frequency components of the RR time series to total heart rate variability).
Description
ECGSYN generates a synthesized ECG signal with usersettable mean heart rate, number of beats, sampling frequency, waveform morphology (P, Q, R, S, and T timing, amplitude,and duration), standard deviation of the RR interval, and LF/HF ratio (a measure of the relative contributions of the low and high frequency components of the RR time series to total heart rate variability). Using a model based on three coupled ordinary differential equations, ECGSYN reproduces many of the features of the human ECG, including beattobeat variation in morphology and timing, respiratory sinus arrhythmia, QT dependence on heart rate, and Rpeak amplitude modulation. The output of ECGSYN may be employed to assess biomedical signal processing techniques which are used to compute clinical statistics from the ECG.
Three implementations are available:
 A version for Matlab and Octave (sources)
 A version in C (sources; readytorun binaries for GNU/Linux, Solaris, and MSWindows are also available)
 A Java applet; the Java sources are also available)
All three forms of the code are freely available and can be downloaded as a single gzipcompressed tar archive, ecgsyn.tar.gz. The algorithms used by ECGSYN are described in an accompanying paper, titled "A dynamical model for generating synthetic electrocardiogram signals [1].
Usage notes
Current implementations of ECGSYN allow the user to modify the morphology of the PQRST cycle, which was not a feature of the original ECGSYN described in the paper. The angle of each attractor (P, Q, R, S and T) around the limit cycle is set by ti (initially, [70 15 0 15 100]*pi/180). Their positions above or below the z=0 plane are set by bi and the widths of the waveform components are given by ai. Since ti=0 defines the placement of the Rpeak, the ordering of each element of ti, ai and bi is [P Q R S T]. The bi and the ti are stretched by the square root of the reciprocal mean RR interval, as suggested by Bazett's (empirical) formula relating the QT interval to the heart rate. This transformation does not cancel out the reduction of the interattractor angular distance that arises 'naturally' from augmented heart rates in this model.
Of related interest is ECGwaveGen [2], a Matlab/Octave application that generates (nonrealistic) ECGlike test waveforms with welldefined characteristics as specified in ANSI/AAMI EC13:1992 (American National Standard: Cardiac Monitors, Heart Rate Meters, and Alarms).
Release notes
ECGSYN was contributed to PhysioNet by Patrick McSharry from the Department of Engineering Science, University of Oxford, and by Gari Clifford of the Laboratory for Computational Physiology at MIT. A Java Applet was contributed by Mauricio Villarroel of the Universidad Católica Boliviana.
References
 McSharry PE, Clifford GD, Tarassenko L, Smith L. A dynamical model for generating synthetic electrocardiogram signals. IEEE Transactions on Biomedical Engineering 50(3): 289294; March 2003.
 Floyd Harriott. ECGwaveGen. PhysioNet. https://physionet.org/content/ecgwavegen/
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GNU General Public License version 3
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Topics:
generator
simulation
ecg
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