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<body style="line-height: 16pt" onunload="CloseFltwin()"><div
class="pgbrk" style="padding-top: 48pt"><div
style="line-height: 26pt; text-align: center"><span class="f18sbB"
style="font-size: 24pt"><a name="a301989888"></a><a name="a301989889"
></a>CVSim User Manual</span></div></div><div class="pgbrk"
style="padding-top: 48pt"><div style="line-height: 22pt"><span
class="f18sbB" style="font-size: 20pt"><a name="a301989896"></a><a
name="a301996040"></a><a name="a301996041"></a><a name="a301989897"
></a> 1 Introduction</span></div><div
style="line-height: 12pt; padding-top: 20pt"><span
style="font-family: serif">The Cardiovascular Simulator, otherwise
known as CVSim, is a hemodynamic simulation developed by the MIT Laboratory
for Computational Physiology. </span></div></div><div class="pgbrk"
style="padding-top: 48pt"><div style="line-height: 22pt"><span
class="f18sbB" style="font-size: 20pt"><a name="a301989905"></a><a
name="a301996051"></a><a name="a301996052"></a><a name="a301989906"
></a> 2 Installation</span></div><div
style="line-height: 18pt; padding-top: 24pt"><span class="f16sb"
style="color: blue"><a name="a301996060"></a><a name="a301996061"
></a><a name="a301989910"></a> 2.1 Supported Platforms</span
></div><div style="line-height: 12pt; padding-top: 16pt"><span
style="font-family: serif">CVSim has been tested on the following
platforms: </span></div><div class="p6"
style="line-height: 12pt; text-indent: -5.9%; padding-left: 5.9%"
><span style="font-family: serif"> • Windows XP </span
></div><div class="p6"
style="line-height: 12pt; text-indent: -5.9%; padding-left: 5.9%"
><span style="font-family: serif"> • Mac OS X PPC</span
></div><div class="p6"
style="line-height: 12pt; text-indent: -5.9%; padding-left: 5.9%"
><span style="font-family: serif"> • Mac OS X i386</span
></div><div class="p6"
style="line-height: 12pt; text-indent: -5.9%; padding-left: 5.9%"
><span style="font-family: serif"> • Fedora Core 4</span
></div><div class="p6"
style="line-height: 12pt; text-indent: -5.9%; padding-left: 5.9%"
><span style="font-family: serif"> • Fedora Core 5</span
></div><div class="p6"
style="line-height: 12pt; text-indent: -5.9%; padding-left: 5.9%"
><span style="font-family: serif"> • Red Hat Enterprise
Linux 4</span></div><div style="line-height: 12pt; padding-top: 10pt"
><span style="font-family: serif">CVSim is not supported on the following
platforms:</span></div><div class="p6"
style="line-height: 12pt; text-indent: -5.9%; padding-left: 5.9%"
><span style="font-family: serif"> • Solaris</span
></div><div style="line-height: 18pt; padding-top: 24pt"><span
class="f16sb" style="color: blue"><a name="a301996326"></a><a
name="a301996327"></a><a name="a301990161"></a> 2.2 Installing
Java Web Start</span></div><div
style="line-height: 12pt; padding-top: 16pt"><span
style="font-family: serif">In order to run CVSim, you need to install
Java Web Start. Java Web Start is part of the Java Runtime Engine
(JRE). If you are using Windows or Linux, follow the <span
style="color: blue; text-decoration: underline"><a
href="http://java.sun.com/javase/6/webnotes/install/index.html">instructions</a
></span> on the Sun website to install JRE 6. If you are using Linux,
you need to perform an <span
style="color: blue; text-decoration: underline"><a
href="http://java.sun.com/javase/6/webnotes/install/jre/manual-plugin-install-linux.html"
>extra step</a></span> and manually install the Java Plugin in your
web browser. If you are using Mac OS X, run Software Update from the
System Preferences. Install Java for Mac OS X 10.4, Release 5.</span
></div><div class="p6" style="line-height: 12pt"><span
style="font-family: serif">The first time you run CVSim, you will
see a security warning that asks you, "The application’s
digital signature cannot be verified. Do you want to run the application?".
Click "Run". If you want to avoid that warning in the future,
check the "Always trust content from this publisher" box.
If you are using Internet Explorer, the security warning may be displayed
behind your browser. </span></div></div><div class="pgbrk"
style="padding-top: 48pt"><div style="line-height: 22pt"><span
class="f18sbB" style="font-size: 20pt"><a name="a301990180"></a><a
name="a301996545"></a><a name="a301996546"></a><a name="a301990181"
></a> 3 CVSim Window Components</span></div><div
style="line-height: 12pt; padding-top: 20pt"><span
style="font-family: serif">The CVSim window is divided into four sections,
a Simulation Parameters pane, a Graphics pane, a Strip Chart, and
a Plot. There is also a toolbar with simulation controls.</span></div
><div class="p6"><span style="font-family: serif"><img
src="user_manual.htm.graphics/cvsim_gui_annotated_small1.jpg"
alt="Z:\slow\Katie\cvsim\cvsim_gui_annotated_small.jpg"></span></div
><div class="p6" style="line-height: 12pt"><span
style="font-family: serif">The Simulation Controls toolbar allows
the user to stop and start the simulation and turn the control systems
on and off. The Simulation Parameters pane displays the simulation
variables and outputs. The Graphics pane displays an anatomical and
circuit representation of the simulation model. The strip chart allows
the user to plot simulation outputs versus time. The strip chart behavior
is based on an electrocardiogram (ECG) strip chart recorder. Like
an ECG signal, the strip chart data scrolls from right to left. The
plot allows the user to plot simulation outputs versus one another.</span
></div></div><div class="pgbrk" style="padding-top: 48pt"><div
style="line-height: 22pt"><span class="f18sbB" style="font-size: 20pt"
><a name="a301990185"></a><a name="a301996556"></a><a name="a301996557"
></a><a name="a301990186"></a> 4 Simulation Controls</span></div
><div style="line-height: 12pt; padding-top: 20pt"><span
style="font-family: serif">The Simulation Controls toolbar contains
the following components:</span></div><div class="p6"
style="text-indent: -5.9%; padding-left: 5.9%"><span
style="font-family: serif"> • <img
src="user_manual.htm.graphics/go2.gif"
alt="C:\Documents and Settings\Katie\My Documents\Work\cvsim\trunk\devel\java\classes\icons\go.gif"
> Start the simulation</span></div><div class="p6"
style="text-indent: -5.9%; padding-left: 5.9%"><span
style="font-family: serif"> • <img
src="user_manual.htm.graphics/stop3.gif"
alt="C:\Documents and Settings\Katie\My Documents\Work\cvsim\trunk\devel\java\classes\icons\stop.gif"
> Stop the simulation</span></div><div class="p6"
style="text-indent: -5.9%; padding-left: 5.9%"><span
style="font-family: serif"> • <img
src="user_manual.htm.graphics/ABgo4.gif"
alt="C:\Documents and Settings\Katie\My Documents\Work\cvsim\trunk\devel\java\classes\icons\ABgo.gif"
> Turn on the arterial baroreflex control system</span></div><div
class="p6" style="text-indent: -5.9%; padding-left: 5.9%"><span
style="font-family: serif"> • <img
src="user_manual.htm.graphics/ABstop5.gif"
alt="C:\Documents and Settings\Katie\My Documents\Work\cvsim\trunk\devel\java\classes\icons\ABstop.gif"
> Turn off the arterial baroreflex control system</span></div><div
class="p6" style="text-indent: -5.9%; padding-left: 5.9%"><span
style="font-family: serif"> • <img
src="user_manual.htm.graphics/CPgo6.gif"
alt="C:\Documents and Settings\Katie\My Documents\Work\cvsim\trunk\devel\java\classes\icons\CPgo.gif"
> Turn on the cardiopulmonary reflex control system</span></div><div
class="p6" style="text-indent: -5.9%; padding-left: 5.9%"><span
style="font-family: serif"> • <img
src="user_manual.htm.graphics/CPstop7.gif"
alt="C:\Documents and Settings\Katie\My Documents\Work\cvsim\trunk\devel\java\classes\icons\CPstop.gif"
> Turn off the cardiopulmonary reflex control system</span></div><div
style="line-height: 12pt; padding-top: 10pt"><span
style="font-family: serif">Watch the <span
style="color: blue; text-decoration: underline"><a
href="http://penelope.mit.edu/physiotools/cvsim_gui/demos/controls.htm"
>Simulation Controls Demo</a></span>.</span></div></div><div
class="pgbrk" style="padding-top: 48pt"><div style="line-height: 22pt"
><span class="f18sbB" style="font-size: 20pt"><a name="a301991201"
></a><a name="a301996815"></a><a name="a301996816"></a><a
name="a301991199"></a> 5 Simulation Variables</span></div><div
style="line-height: 12pt; padding-top: 20pt"><span
style="font-family: serif">Watch the <span
style="color: blue; text-decoration: underline"><a
href="http://penelope.mit.edu/physiotools/cvsim_gui/demos/variables.htm"
>Simulation Variables Demo</a></span>.</span></div></div><div
class="pgbrk" style="padding-top: 48pt"><div style="line-height: 22pt"
><span class="f18sbB" style="font-size: 20pt"><a name="a301990405"
></a><a name="a301996826"></a><a name="a301996827"></a><a
name="a301990406"></a> 6 Graphics Pane</span></div><div
style="line-height: 12pt; padding-top: 20pt"><span
style="font-family: serif">Watch the <span
style="color: blue; text-decoration: underline"><a
href="http://penelope.mit.edu/physiotools/cvsim_gui/demos/graphics.htm"
>Graphics Pane Demo</a></span>.</span></div></div><div class="pgbrk"
style="padding-top: 48pt"><div style="line-height: 22pt"><span
class="f18sbB" style="font-size: 20pt"><a name="a301990412"></a><a
name="a301996837"></a><a name="a301996838"></a><a name="a301990413"
></a> 7 Strip Chart and Plot</span></div><div
style="line-height: 12pt; padding-top: 20pt"><span
style="font-family: serif">Watch the <span
style="color: blue; text-decoration: underline"><a
href="http://penelope.mit.edu/physiotools/cvsim_gui/demos/plots.htm"
>Strip Chart and Plot Demo</a></span>.</span></div></div><div
class="pgbrk" style="padding-top: 48pt"><div style="line-height: 22pt"
><span class="f18sbB" style="font-size: 20pt"><a name="a301990417"
></a><a name="a301996848"></a><a name="a301996849"></a><a
name="a301990418"></a> 8 Simulating Patients</span></div></div
></body></html>