Cerebral Vasoregulation in Diabetes 1.0.0

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Visit	Physionet Directory	Directory	Protocol	Filename	Format	Channels	Sampling rate	Label	description	units	Calibration	Equipment	Device output sampling rate	Experiment
Day 1	Not Uploaded	Screening	ICF
			PCP permission
			Blood draw
			Retinal imaging
Day 1	Not Uploaded	TCD	TCD window
Day 1	Data/Labview/ Head-upTilt_ Day1	Head-up tilt test	Deep breathing at 0.1Hz
			Valsalva maneuver
			5-minutes head-up tilt test	S#####DA.dat		1		marker
						2		ECG	ECG
						3		ABP	finger blood pressure waveform	mmHg	*100	Finapress	100 HZ
						4		Mcar	right middle cerebral artery flow velocity waveform	cm/s		Multi		empty channels not recorded
						5		Mcal	left middle cerebral artery flow velocity waveform	cm/s		MultiDop X4, DWL Neuroscan Inc, Sterling, VA	50 Hz	empty channels not recorded
						6		Radi	radial artery flow velocity waveform	c,/s				empty channels not recorded
						7		Thermst	respiration with nasal thermistor	relative		thermisor
						8		Flow rate	respiration flow rate			Capnomac Ultima
						9		O2	end tidal O2	mmHg	*9.09	Capnomac Ultima
						10		CO2	end tidal CO2	mmHg	*7.74	Capnomac Ultima

Day 1	Not Uploaded	Portapress	Beat-to-beat BP	Portapress resting continuous beat-to-beat BP during head-up tilt (day 1) recording
				S####D_Portapress.dat



				Note: This was recorded during Head-up tilt test. Not all the subjects had a recording.
				Note: During recording the machine did not work proprerly, so files which are labeled as Beat1, Beat2, Beat 3 and Beat4. It means those files are from the same subject.


Day 1	Data/Pedar	Pedar	12 minute Walking test	Walk test 1&2 ( walk1 around 11 am and walk 2 in the afternoon, normal hallway walking for 12 min recorded with EMG channels using ME6000) and foot pressure distribution using pedar mobile, some subjects also have Portapress beat-to-beat blood pressure)								ME6000

				Walking test- foot pressure distribution and walking characteristics using Pedar Mobile
				S####DA.ASC_Pedar	DAT
				S####DA.ASC_Pedar	HEA
						16
						header: filename, left insole #, right insole #, mean step left, mean step right, min and max step, total time (s econds), distance ( meters),velocity (m/s)
						1	step_no
						2	foot
						3	max. force[N]
						4	mean force[N]
						5	max pressure [N/cmÂ²]
						6	start
						7	start in % of total time
						8	stride
						9	step
						10	stance
						11	stance in % of stride
						12	swing
						13	swing in %
						14	init double in %
						15	single limb support %
						16	terminate double %

Day 2	Data/Labview/ Head-upTilt_ Day2	Labview	Head up tilt	Vasoreactivity, Valsalva maneuver, Head up tilt
		TCD	with TCD
			Valsalva manuever
			5 min supine baseline	S####DB.dat	Labview	10	500 Hz			V
			3 min hyperventilation
			3 min CO2 rebreathing			1		marker						baseline	Valsalva maneuver	hyperventilation	Co2 rebreathing	head-up tilt	baseline
			5 min supine rest			2		ECG	ECG
			Head up tilt 10 min			3		ABP	finger blood pressure waveform	mmHg	*100	Finapress	100 HZ
						4		Mcar	right middle cerebral artery flow velocity waveform	cm/s		Multi
						5		Mcal	left middle cerebral artery flow velocity waveform	cm/s		MultiDop X4, DWL Neuroscan Inc, Sterling, VA;	50 Hz
						6		Radi	radial artery flow velocity waveform	c,/s
						7		Thermst	respiration with nasal thermistor	relative		thermisor
						8		Flow rate	respiration flow rate			Capnomac Ultima
						9		O2	end tidal O2	mmHg	*9.09	Capnomac Ultima
						10		CO2	end tidal CO2	mmHg	*7.74	Capnomac Ultima


Day 2	Data/Labview/Sit-To-Stand	labview-sit-to-stand	Sit-to stand with eyes open and closed	Sit-to-stand Test
			5 min sitting with eyes open on balance platform with simultaneous cardiovascular, TCD
			5 min standing with eyes open on balance platform with simultaneous cardiovascular, TCD and balance measures
			5 min sitting with eyes closed on balance platform with simultaneous cardiovascular, TCD
			5 min standing with eyes closed on balance platform with simultaneous cardiovascular, TCD and balance measures
				S####DC.dat	Labview	15	1000 Hz			V

						1		marker						sitting 5min	standing eyes open 3min	sitting	standing eyes closed
						2		ECG	ECG
						3		ABP	finger blood pressure waveform	mmHg	*100	Finapress
						4		Mcar	right middle cerebral artery flow velocity waveform	cm/s		Multi
						5		Mcal	left middle cerebral artery flow velocity waveform	cm/s		MultiDop X4, DWL Neuroscan Inc, Sterling, VA;
						6		Radi	radial artery flow velocity waveform	cm/s
						7		Thermst	respiration with nasal thermistor	relative		thermisor
						8		Flow rate	respiration flow rate	ml/s		Capnomac Ultima
						9		O2	end tidal O2	mmHg	*9.09	Capnomac Ultima
						10		CO2	end tidal CO2	mmHg	*7.74	Capnomac Ultima
						11		fx	sway trajectory in mediolateral direction	mm		Kistler Force plate, Amherst MA
						12		fy	sway trajectory in anteroposterior direction	mm
						13		fz	sway trajectory in vertical direction	mm
						14		px	center of pressure x component	mm
						15		py	center of pressure x component	mm

				S#####DC.ch1-10.dat	Labview	10	1000 Hz

						1		marker
						2		ECG	ECG
						3		ABP	finger blood pressure waveform	mmHg	*100	Finapress
						4		Mcar	right middle cerebral artery flow velocity waveform	cm/s		Multi
						5		Mcal	left middle cerebral artery flow velocity waveform	cm/s		MultiDop X4, DWL Neuroscan Inc, Sterling, VA;
						6		Radi	radial artery flow velocity waveform	cm/s
						7		Thermst	respiration with nasal thermistor	relative		thermisor
						8		Flow rate	respiration flow rate	ml/s		Capnomac Ultima
						9		O2	end tidal O2	mmHg	*9.09	Capnomac Ultima
						10		CO2	end tidal CO2	mmHg	*7.74	Capnomac Ultima





Day 3	Not uploaded	3T MRI	Anatomical MRI	MRI- anatomical, CBF regional perfusiona dn paerfusion in vascular territories; CO2 vasoreactivity to hyperventilation and C02 rebreathing
			Perfusion MRI	3Tesla GE Signa Vhi or Excite scanner and phase arrays head coil ( GE Medical Systmes, Milwaukee, WI)
				MP-RAGE					MP-RAGE) (repetition	ml or % of total brain volume
									time [TR]/echo time [TE]/inversion time [TI] 7.8/3.1/600
									msec, 3.0 mm slice thickness, 52 slices, bandwidth 122 Hz
									per pixel, flip angle 10°, 24 cm 24 cm field of view [FOV],
									256 192 matrix size)

				FLAIR					fluid-attenuated inversion recovery
									(FLAIR) (TR/TE/TI 11,000/161/2,250 msec, 5 mm slice
									thickness, 30 slices, bandwidth 122 Hz per pixel, flip angle
									90°, 24 cm 24 cm FOV, 256 160 matrix size),

				DWI					diffusion-weighted image (b value of 1,000 seconds/
									mm2, TR/TE 10,000/86.6 msec, 5 mm slice thickness, bandwidth
									250 kHz, 128 128 matrix size

				CASL	CBF				three-dimensional stack of	mL · 100 g1 · min1
									interleaved spirals fast spin echo sequence (TR/TE 6,000/
									23.8 msec, echo train length 66, with a 18 18 cm FOV, in
									the coronal plane and 64 slices with thickness 3.8 mm, eight
				see Zhao et al. Neurology 2009 ;72:643-649 for procecessing details					spiral interleaves, two averages and a bandwidth62.5 kHz).
				Transcranial Doppler

Day 4	Not uploaded	Neurological Examination	The physician assessed for the presence of neuropathy using the neuropathy checklist.