% Parameters characterizing the cardiovascular simulator and its execution.
%
% The following parameter assignment format must be maintained:
% parameter: numerical_value
%
% Parameters labelled {*} cannot be adjusted on-line; any changes to these 
% parameters will simply be ignored.

% Integration and sampling parameters

	% Integration/Sampling frequency of generated signals (Def: 125 Hz) {*}
	% WARNING -- smaller sampling frequency leads to greater
	% integration errors
	Fs: 125

	% Total integration time (s) {*}
	% Set time: 1000 for cardiac function/venous return curves
	% (Simulator will stop integration as soon as the computation
	% of the curves is complete.)
	time: 300

% Display parameters

	% Waveforms to be viewed
	% Simulated waveforms and corresponding numerical values
	% | Pl 0 | Pa 1 | Pv 2 | Pr 3 | Ppa 4 | Ppv 5 |
	% | Pth 6 | Palv 7 | Pra 8 | Ql 9 | Qa 10 | Qv 11 |
	% | Qr 12 | Qpa 13 | Qpv 14 | Qlu 15 | qpv 16 | ql 17 |
	% | qa 18 | qv 19 | qr 20 | qpa 21 | Cls 22 | Crs 23 |
	% | Qvo 24 | Ra 25 | F 26 | El 27 | Er 28 |
	% Place single space between each waveform number
	% For no waveforms, write waveform: -1
	waveform: 0 1

	% Annotation to be viewed
	% 0 - no
	% 1 - yes
	annotations: 1

	% Time duration of window of displayed waveforms (s)
	% For best viewing, set window = WAVE time window
	% See View... option on WAVE menu bar for adjustment
	% of WAVE time window
	window: 20

	% Time period between waveform display updates (s)
	% WARNING -- smaller step values lead to display errors
	step: 2

	% Cardiac function/venous return curve plotting format
	% -1 - no plot
	%  0 - single plot per window; x-axis: mPra
	%  1 - multiple plots per window; x-axis: mPra
	%  2 - single plot per window; x-axis: mPa 
	%  3 - multiple plots per window; x-axis: mPa
	%  (Note: 2 and 3 are only applicable to heart-lung unit)
	numerics: 0

% Status parameters
% These parameters override any of the settings below.

	% Status of heart and circulation {*}
	% 0 - intact circulation
	% 1 - heart-lung unit
	% 2 - systemic circulation
	preparation: 0

	% Status of baroreflex system {*}
	% 0 - arterial and cardiopulmonary baroreflexes off
	% 1 - arterial baroreflex on only
	% 2 - cardiopulmonary baroreflex on only
	% 3 - arterial and cardiopulmonary baroreflexes on
	baro: 0

	% Status of direct neural coupling mechanism
	% between Qlu and F {*}
	% 0 - off
	% 1 - on
	dncm: 0

	% Status of breathing {*}
	% 0 - no breathing
	% 1 - fixed-rate breathing
	% 2 - random-interval breathing
	breathing: 0

	% Status of bandlimited disturbance to Ra {*}
	% 0 - off
	% 1 - on
	dra: 0

	% Status of 1/f disturbance to F {*}
	% 0 - off
	% 1 - on
	df: 0

% Heart and circulation parameters
%
% These parameters completely characterize the intact 
% circulation.  Some of these parameters also characterize 
% the heart-lung unit [HLU] and systemic circulation [SC] 
% as specified below.

	% Left ventricle

		% Differential end-systolic compliance at 
		% unstressed volume (Def: 0.4 ml/mmHg) [HLU]
		Cls: 0.4

		% Differential diastolic compliance at 
		% unstressed volume (Def: 10 ml/mmHg) [HLU]
		Cld: 10

		% Unstressed volume (Def: 15 ml) [HLU]
		Qlo: 15

		% Maximum volume (Def: 270 ml) [HLU]
		Qlmax: 270

		% Maximum pressure (Def: 260 mmHg) [HLU]
		Plmax: 260

		% Resistance (Def: 0.006 mmHg-s/ml) [HLU]
		Rl: 0.006

	% Systemic arteries

		% Compliance (Def: 1.6 ml/mmHg) [SC]
		Ca: 1.6

		% Unstressed volume (Def: 715 ml) [SC]
		Qao: 715

		% Resistance (Def: 1.0 mmHg-s/ml) [SC]
		Ra: 1.0

	% Systemic veins

		% Compliance (Def: 100 ml/mmHg) [SC]
		Cv: 100

		% Unstressed volume (Def: 2600 ml) [SC]
		Qvo: 2600

		% Resistance when Starling resistor is 
		% fully opened (Def: 0.02 mmHg-s/ml) [HLU,SC]
		Rv: 0.02

		% Chamber pressure -- atmospheric pressure (Def: 0 mmHg)
		% Also functional reserve alveolar pressure
		% [HLU,SC]
		Pvc: 0

	% Right ventricle

		% Differential end-systolic compliance at 
		% unstressed volume (Def: 1.2 ml/mmHg) [HLU,SC]
		Crs: 1.2

		% Differential diastolic compliance at 
		% unstressed volume (Def: 12.5 ml/mmHg) [HLU,SC]
		% This parameter cannot be updated for preparation: 2
		% when Crd is automatically being stepped up through Crds.
		Crd: 12.5

		% Unstressed volume (Def: 15 ml) [HLU,SC]
		Qro: 15

		% Maximum volume (Def: 235 ml) [HLU,SC]
		Qrmax: 235

		% Maximum pressure (Def: 70 mmHg) [HLU,SC]
		Prmax: 70

		% Resistance (Def: 0.003 mmHg-s/ml) [HLU,SC]
		Rr: 0.003

	% Pulmonary arteries

		% Compliance (Def: 4.3 ml/mmHg) [HLU]
		Cpa: 4.3

		% Unstressed volume (Def: 90 ml) [HLU]
		Qpao: 90

		% Resistance when all Starling resistors are 
		% fully opened (Def: 0.09 mmHg-s/ml) [HLU]
		Rpa: 0.09

	% Pulmonary veins

		% Compliance (Def: 8.4 ml/mmHg) [HLU]
		Cpv: 8.4

		% Unstressed volume (Def: 490 ml) [HLU]
		Qpvo: 490

		% Resistance (Def: 0.01 mmHg-s/ml) [HLU]
		Rpv: 0.01

	% System

		% Total blood volume (Def: 5000 ml)
		Qtot: 5000

		% Heart rate (Def: 1.2 bps) [HLU,SC]
		F: 1.2

% Additional HLU parameters

	% Systemic arterial constant pressure reservoir (Def: 100 mmHg)
	% May only be updated for preparation: 1 when Pa is not
	% automatically stepped up through Pas.
	Pa: 100

	% Systemic venous constant pressure reservoir (Def: 5 mmHg)
	% May only be updated for preparation: 1 when Pv is not
	% automatically stepped down through Pvs.
	Pv: 5

	% Step in Pa (Def: 1000 mmHg for cardiac output curve) {*}
	%            (Def: 30 for cardiac output versus arterial pressure)
	% If Pas <= Plmax-Pas-10, then Pa is stepped up 
	% as follows: 30:Pas:Plmax-10.  Else, Pa is assigned
	% the scalar value above.
	Pas: 1000

	% Step in Pv (Def: 2 mmHg for cardiac output curve) {*}
	%            (Def: 100 mmHg for cardiac output versus arterial pressure)
	% If Pvs <= round((Qrmax-Qro-20)/Crd)+3-1, then 
	% Pv is stepped down as follows: 
	% [round((Qrmax-Qro-20)/Crd)+3:-Pvs:0, Pth+1].  Else, Pv
	% is assigned the scalar value above.
	Pvs: 2

% Additional SC parameters

	% Pulmonary arterial constant pressure reservoir (Def: 24 mmHg)
	% May only be updated for preparation: 2.
	Ppa: 24

	% Mean systemic pressure (Def: 6.9 mmHg) {*}
	% This parameter can be updated by adjusting the systemic
	% arteries and veins parameters. 
	Pms: 6.9

	% Step in Crd (Def: 5 ml/mmHg for venous return curve) {*}
	%	      (Def: 100 ml/mmHg for constant Crd)
	% If Crds <= 60-Crs, then Crd is stepped up as follows:
	% Crs:Crds:60.  Else, Crd is assigned the scalar value
	% above.
	Crds: 5

% Short-term regulatory system parameters

	% Static gain control of the beta-sympathetic 
	% nervous system (Def: 1 unitless)
	bgain: 1

	% Static gain control of the alpha-sympathetic 
	% nervous system (Def: 1 unitless)
	again: 1

	% Static gain control of the parasympathetic 
	%nervous system (Def: 1 unitless)
	pgain: 1

	% Arterial baroreflex

		% Setpoint pressure (Def: 94 mmHg)
		Pasp: 94

		% Saturation factor (Def: 18 mmHg)
		% (if Sa == 9999, then no saturation)		
		Sa: 18 

		% Static gain control of F parasympathetic
		% baroreflex (Def: 12 unitless)
		againfp: 12

		% Static gain control of F beta-sympathetic
		% baroreflex (Def: 12 unitless)
		againfs: 12		

		% Static gain control of Cls, Crs beta-sympathetic
		% baroreflex (Def: 12 unitless)
		againc: 12

		% Static gain control of Ra alpha-sympathetic
		% baroreflex (Def: 9 unitless)
		againr: 9 

		% Static gain control of Qvo alpha-sympathetic
		% baroreflex (Def: 9 unitless)
		againq: 9

	% Cardiopulmonary baroreflex

		% Setpoint pressure (Def: 6.6 mmHg)
		Pratrsp: 6.6

		% Saturation factor (Def: 5 mmHg)
		% (if Sc == 9999, then no saturation)
		Sc: 5 

		% Static gain control of F parasympathetic
		% baroreflex (Def: 0 unitless)
		cgainfp: 0

		% Static gain control of F beta-sympathetic
		% baroreflex (Def: 0 unitless)
		cgainfs: 0

		% Static gain control of Cls, Crs beta-sympathetic
		% baroreflex (Def: 0 unitless)
		cgainc: 0

		% Static gain control of Ra alpha-sympathetic
		% baroreflex (Def: 9 unitless)
		cgainr: 9

		% Static gain control of Qvo alpha-sympathetic
		% baroreflex (Def: 9 unitless)
		cgainq: 9

	% Direct neural coupling mechanism between respiration and F

		% Static gain control of parasympathetic limb (Def: 1 unitless)
		dgainp: 1

		% Static gain control of beta-sympathetic limb (Def: 1 unitless)
		dgains: 1

% Resting physiologic perturbations parameters

	% Respiration

		% Respiratory cycle period for fixed-rate 
		% breathing (Def: 5 sec)
		Tr: 5

		% Tidal volume (Def: 500 ml)
		Qt: 500

		% Initial functional reserve volume (Def: 2200 ml) {*}
		Qfr: 2200

		% Step amplitude in functional reserve volume (Def: 0 ml)
		Qfrs: 0

		% Dead space of airways (Def: 150 ml)
		Qds: 150

		% Airway resistance (Def: 0.0026 mmHg-s/ml)
		Rair: 0.0026

		% Lung compliance (Def: 252.5 ml/mmHg)
		Clu: 252.5

		% Unstressed volume in lungs (Def: 1190 ml)
		Qluo: 1190

	% Bandlimited disturbance to Ra

		% Frequency cutoff (Def: 0.1 Hz) 
		fco: 0.1

		% Standard deviation of white noise (Def: 0.16 (mmHg-s/ml)/Hz^{1/2})
		stdwr: 0.16

	% 1/f disturbance to F

		% Standard deviation of white noise (Def: 0.0035 (bps)/Hz^{1/2})
		stdwf: 0.0035

		% Alpha exponent (Def: 1 unitless)
		alpha: 1

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