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Human Cardiovascular Model

The human cardiovascular model upon which RCVSIM is based includes three major components. The first component is a lumped parameter model of the pulsatile heart and circulation which may be implemented as an intact preparation, a heart-lung unit preparation designed for measuring cardiac function curves, or a systemic circulation preparation designed for measuring venous return curves. The second component is a short-term regulatory system model which includes an arterial baroreflex system, a cardiopulmonary baroreflex system, and a direct neural coupling mechanism between respiration and heart rate. The final component is a model of resting physiologic perturbations which includes respiration, autoregulation of local vascular beds (exogenous disturbance to systemic arterial resistance), and higher brain center activity impinging on the autonomic nervous system(1/f exogenous disturbance to heart rate).

Figure 1: Electrical circuit analog of the intact human pulsatile heart and circulation. Each box encompassing a circuit element denotes a nonlinear element.
\begin{figure}\centerline{\psfig{figure={epsfig/cvsim1.eps},width=6in,silent=1}} \end{figure}


Ramakrishna Mukkamala (