Response to Valsalva Maneuver in Humans

Version 1.0 - 12 November 2018

When referencing this material, please cite:

Kosinski SA, Carlson BE, Hummel SL, Brook RD, Beard DA. Computational Model-Based Assessment of Baroreflex Function from Response to Valsalva Maneuver. J Appl Physiol 2018 Sep 20. doi: 10.1152/japplphysiol.00095.2018. [Epub ahead of print].

Please also include the standard citation for PhysioNet:

Goldberger AL, Amaral LAN, Glass L, Hausdorff JM, Ivanov PCh, Mark RG, Mietus JE, Moody GB, Peng C-K, Stanley HE. PhysioBank, PhysioToolkit, and PhysioNet: Components of a New Research Resource for Complex Physiologic Signals. Circulation 101(23):e215-e220 [Circulation Electronic Pages; http://circ.ahajournals.org/content/101/23/e215]; 2000 (June 13). [bib]
@article{PhysioNet,
  author    = {Goldberger, Ary L. and Amaral, Luis A. N.
               and Glass, Leon and Hausdorff, Jeffrey M.
               and Ivanov, Plamen Ch. and Mark, Roger G.
               and Mietus, Joseph E. and Moody, George B.
               and Peng, Chung-Kang and Stanley, H. Eugene},
  title     = {{PhysioBank}, {PhysioToolkit}, and {PhysioNet}:
               Components of a New Research Resource for Complex
               Physiologic Signals},
  journal   = {Circulation},
  publisher = {American Heart Association, Inc.},
  volume    = {101},
  number    = {23},
  year      = {2000},
  month     = {June},
  pages     = {e215--e220},
  doi       = {10.1161/01.CIR.101.23.e215},
  issn      = {0009-7322},
  url       = {http://circ.ahajournals.org/content/101/23/e215}
}

Introduction

Functional metrics of autonomic control of heart rate, including baroreflex sensitivity, have been shown to be strongly associated with cardiovascular risk. A decrease in baroreflex sensitivity with aging is hypothesized to represent a contributing causal factor in the etiology of primary hypertension. To assess baroreflex function in human subjects, two complementary methods to simulate the response in heart rate elicited by the Valsalva maneuver were developed and applied to data obtained from a cohort of healthy normal volunteers.

Data Collection

Data was obtained from 27 participants excluding individuals with histories positive for inherited cardiomyopathy, valvular disease, aneurism, dissection, vascular surgery, pulmonary hypertension, connective tissue disease, or stroke. For each such normal healthy subject, baseline blood pressures were measured at 200 Hz during normal respiration prior to one or more instances of a forced expiration into a closed glottis (i.e Valsalva maneuver). The airway pressures achieved during expiration were measured at 10 Hz, with subjects instructed to maintain a pressure exceeding 30 mmHg for at least 10 seconds, though review of the data will show variability in each participant's results. Data collection of both blood and airway pressures continues throughout a recovery period subsequent to each Valsalva maneuver.

Files

The data for 27 subjects are presented here where for a given subject (e.g. norm001) two simultaneous recordings have been made. One is for the blood pressure obtained with a Finapres blood pressure monitor (e.g. norm001_BP) and the other is the thoracic pressure during three Valsalva maneuvers (e.g norm001_P). The thoracic pressure is measured by the subject breathing into a small closed chamber instrumented to measure the chamber pressure. The age and gender associated with each subject are found in the text file demographics.csv.

Contributors

This data was contributed by: Samuel A. Kosinski, Brian E. Carlson, Scott L. Hummel, Robert D. Brook and Daniel A. Beard.

Contact

For further information, please contact:

Brian Carlson
Department of Molecular and Integrative Physiology, University of Michigan
bcarl@umich.edu
Daniel Beard
Department of Molecular and Integrative Physiology, University of Michigan
beardda@umich.edu

Icon  Name                    Last modified      Size  Description
[PARENTDIR] Parent Directory - [   ] RECORDS 2018-11-12 13:04 567 list of record names [TXT] demographics.csv 2018-11-12 13:04 251 [   ] norm001_BP.dat 2018-11-12 13:04 112K digitized signal(s) [   ] norm001_BP.hea 2018-11-12 13:04 178 header file [   ] norm001_P.dat 2018-11-12 13:04 5.6K digitized signal(s) [   ] norm001_P.hea 2018-11-12 13:04 180 header file [   ] norm002_BP.dat 2018-11-12 13:04 100K digitized signal(s) [   ] norm002_BP.hea 2018-11-12 13:04 178 header file [   ] norm002_P.dat 2018-11-12 13:04 5.0K digitized signal(s) [   ] norm002_P.hea 2018-11-12 13:04 177 header file [   ] norm003_BP.dat 2018-11-12 13:04 102K digitized signal(s) [   ] norm003_BP.hea 2018-11-12 13:04 176 header file [   ] norm003_P.dat 2018-11-12 13:04 5.1K digitized signal(s) [   ] norm003_P.hea 2018-11-12 13:04 175 header file [   ] norm004_BP.dat 2018-11-12 13:04 107K digitized signal(s) [   ] norm004_BP.hea 2018-11-12 13:04 178 header file [   ] norm004_P.dat 2018-11-12 13:04 5.3K digitized signal(s) [   ] norm004_P.hea 2018-11-12 13:04 178 header file [   ] norm005_BP.dat 2018-11-12 13:04 80K digitized signal(s) [   ] norm005_BP.hea 2018-11-12 13:04 176 header file [   ] norm005_P.dat 2018-11-12 13:04 4.0K digitized signal(s) [   ] norm005_P.hea 2018-11-12 13:04 178 header file [   ] norm006_BP.dat 2018-11-12 13:04 109K digitized signal(s) [   ] norm006_BP.hea 2018-11-12 13:04 177 header file [   ] norm006_P.dat 2018-11-12 13:04 5.4K digitized signal(s) [   ] norm006_P.hea 2018-11-12 13:04 180 header file [   ] norm007_BP.dat 2018-11-12 13:04 206K digitized signal(s) [   ] norm007_BP.hea 2018-11-12 13:04 179 header file [   ] norm007_P.dat 2018-11-12 13:04 10K digitized signal(s) [   ] norm007_P.hea 2018-11-12 13:04 180 header file [   ] norm008_BP.dat 2018-11-12 13:04 292K digitized signal(s) [   ] norm008_BP.hea 2018-11-12 13:04 179 header file [   ] norm008_P.dat 2018-11-12 13:04 15K digitized signal(s) [   ] norm008_P.hea 2018-11-12 13:04 181 header file [   ] norm009_BP.dat 2018-11-12 13:04 232K digitized signal(s) [   ] norm009_BP.hea 2018-11-12 13:04 178 header file [   ] norm009_P.dat 2018-11-12 13:04 12K digitized signal(s) [   ] norm009_P.hea 2018-11-12 13:04 181 header file [   ] norm010_BP.dat 2018-11-12 13:04 103K digitized signal(s) [   ] norm010_BP.hea 2018-11-12 13:04 178 header file [   ] norm010_P.dat 2018-11-12 13:04 5.2K digitized signal(s) [   ] norm010_P.hea 2018-11-12 13:04 179 header file [   ] norm011_BP.dat 2018-11-12 13:04 168K digitized signal(s) [   ] norm011_BP.hea 2018-11-12 13:04 178 header file [   ] norm011_P.dat 2018-11-12 13:04 8.4K digitized signal(s) [   ] norm011_P.hea 2018-11-12 13:04 178 header file [   ] norm012_BP.dat 2018-11-12 13:04 238K digitized signal(s) [   ] norm012_BP.hea 2018-11-12 13:04 177 header file [   ] norm012_P.dat 2018-11-12 13:04 12K digitized signal(s) [   ] norm012_P.hea 2018-11-12 13:04 181 header file [   ] norm013_BP.dat 2018-11-12 13:04 184K digitized signal(s) [   ] norm013_BP.hea 2018-11-12 13:04 176 header file [   ] norm013_P.dat 2018-11-12 13:04 9.2K digitized signal(s) [   ] norm013_P.hea 2018-11-12 13:04 180 header file [   ] norm014_BP.dat 2018-11-12 13:04 117K digitized signal(s) [   ] norm014_BP.hea 2018-11-12 13:04 176 header file [   ] norm014_P.dat 2018-11-12 13:04 5.8K digitized signal(s) [   ] norm014_P.hea 2018-11-12 13:04 181 header file [   ] norm015_BP.dat 2018-11-12 13:04 135K digitized signal(s) [   ] norm015_BP.hea 2018-11-12 13:04 178 header file [   ] norm015_P.dat 2018-11-12 13:04 6.7K digitized signal(s) [   ] norm015_P.hea 2018-11-12 13:04 180 header file [   ] norm016_BP.dat 2018-11-12 13:04 348K digitized signal(s) [   ] norm016_BP.hea 2018-11-12 13:04 178 header file [   ] norm016_P.dat 2018-11-12 13:04 17K digitized signal(s) [   ] norm016_P.hea 2018-11-12 13:04 179 header file [   ] norm017_BP.dat 2018-11-12 13:04 353K digitized signal(s) [   ] norm017_BP.hea 2018-11-12 13:04 179 header file [   ] norm017_P.dat 2018-11-12 13:04 18K digitized signal(s) [   ] norm017_P.hea 2018-11-12 13:04 179 header file [   ] norm018_BP.dat 2018-11-12 13:04 263K digitized signal(s) [   ] norm018_BP.hea 2018-11-12 13:04 178 header file [   ] norm018_P.dat 2018-11-12 13:04 13K digitized signal(s) [   ] norm018_P.hea 2018-11-12 13:04 178 header file [   ] norm019_BP.dat 2018-11-12 13:04 181K digitized signal(s) [   ] norm019_BP.hea 2018-11-12 13:04 177 header file [   ] norm019_P.dat 2018-11-12 13:04 9.1K digitized signal(s) [   ] norm019_P.hea 2018-11-12 13:04 180 header file [   ] norm020_BP.dat 2018-11-12 13:04 287K digitized signal(s) [   ] norm020_BP.hea 2018-11-12 13:04 178 header file [   ] norm020_P.dat 2018-11-12 13:04 14K digitized signal(s) [   ] norm020_P.hea 2018-11-12 13:04 179 header file [   ] norm021_BP.dat 2018-11-12 13:04 313K digitized signal(s) [   ] norm021_BP.hea 2018-11-12 13:04 177 header file [   ] norm021_P.dat 2018-11-12 13:04 16K digitized signal(s) [   ] norm021_P.hea 2018-11-12 13:04 179 header file [   ] norm022_BP.dat 2018-11-12 13:04 553K digitized signal(s) [   ] norm022_BP.hea 2018-11-12 13:04 178 header file [   ] norm022_P.dat 2018-11-12 13:04 28K digitized signal(s) [   ] norm022_P.hea 2018-11-12 13:04 181 header file [   ] norm023_BP.dat 2018-11-12 13:04 260K digitized signal(s) [   ] norm023_BP.hea 2018-11-12 13:04 179 header file [   ] norm023_P.dat 2018-11-12 13:04 13K digitized signal(s) [   ] norm023_P.hea 2018-11-12 13:04 181 header file [   ] norm024_BP.dat 2018-11-12 13:04 237K digitized signal(s) [   ] norm024_BP.hea 2018-11-12 13:04 178 header file [   ] norm024_P.dat 2018-11-12 13:04 12K digitized signal(s) [   ] norm024_P.hea 2018-11-12 13:04 179 header file [   ] norm025_BP.dat 2018-11-12 13:04 193K digitized signal(s) [   ] norm025_BP.hea 2018-11-12 13:04 178 header file [   ] norm025_P.dat 2018-11-12 13:04 9.7K digitized signal(s) [   ] norm025_P.hea 2018-11-12 13:04 179 header file [   ] norm026_BP.dat 2018-11-12 13:04 221K digitized signal(s) [   ] norm026_BP.hea 2018-11-12 13:04 178 header file [   ] norm026_P.dat 2018-11-12 13:04 11K digitized signal(s) [   ] norm026_P.hea 2018-11-12 13:04 179 header file [   ] norm027_BP.dat 2018-11-12 13:04 369K digitized signal(s) [   ] norm027_BP.hea 2018-11-12 13:04 178 header file [   ] norm027_P.dat 2018-11-12 13:04 18K digitized signal(s) [   ] norm027_P.hea 2018-11-12 13:04 181 header file

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Updated Friday, 28 October 2016 at 16:58 EDT

PhysioNet is supported by the National Institute of General Medical Sciences (NIGMS) and the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under NIH grant number 2R01GM104987-09.