Safety and Preliminary Efficacy of Intranasal Insulin for Cognitive Impairment in Parkinson Disease and Multiple System Atrophy 1.0
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Study No | Pharmacy | excluded | IversusP | Pre-Post | Age | Gender | Etnicity | Smoking | Height (in) | Weight | BMI | Disease | Disease Duration | SBP | DBP | HR | Walk-Duration | Walk-NoSteps | AverStride (in) | MOCA | Glucose | SBP | DBP | HR | BMI 2 | Walk-Duration 2 | Walk-NoSteps 2 | AverStrid (in) 2 | Gait Speed 2 | HnH | PGI-I | BDI | MOCA 2 | F#words | A#words | S#words | FAS | Pre-Post | Glucose 2 | MOCA 3 | Walk-Duration 3 | Walk-NoSteps 3 | AverStrid (in) 3 | Gait Speed 3 | HnH 2 | PGI-I 2 | BDI 2 | F#words 2 | A#words 2 |
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1 | n/a | excluded/screen failure | Post | ||||||||||||||||||||||||||||||||||||||||||||||
2 | 1-PD | 0 | Pre | 79 | 1 | w | 0 | 69 | 176 | 26.02 | PD | 3 | 154 | 88 | 66 | 5.81 | 9 | 16 | 26 | 84 | 148 | 82 | 62 | 26.02 | 4.76 | 7 | 21 | 1.050420168 | 2.5 | 3 | 17 | 27 | 16 | 7 | 8 | 31 | Post | 73 | 24 | 5.45 | 9 | 16 | 0.917431193 | 2.5 | 3 | 13 | 6 | 4 | |
3 | 2-PD | 1 | Pre | 64 | 1 | w | 0 | 76.5 | 184 | 22.1 | PD | 9 | 129 | 83 | 70 | 3.72 | 7 | 21 | 30 | 89 | 129 | 83 | 70 | 22.1 | 3.9 | 7 | 21 | 1.282051282 | 2.5 | 3 | 3 | 30 | 15 | 16 | 15 | 46 | Post | 83 | 29 | 4.08 | 7 | 21 | 1.225490196 | 2.5 | 3 | 3 | 15 | 17 | |
4 | 3-PD | 0 | Pre | 53 | 2 | w | 0 | 67 | 155 | 24.3 | PD | 5 | 113 | 69 | 70 | 3.84 | 8 | 18 | 28 | 98 | 113 | 69 | 70 | 24.3 | 4.4 | 8 | 18 | 1.136363636 | 2.5 | 3 | 15 | 29 | 11 | 11 | 12 | 34 | Post | 98 | 30 | 4.55 | 8 | 18 | 1.098901099 | 2.5 | 3 | 13 | 11 | 8 | |
5 | 4-PD | 1 | Pre | 71 | 1 | a | 0 | 68 | 157 | 23.9 | PD | 17 | 114 | 74 | 62 | 3.37 | 7 | 21 | 26 | 83 | 114 | 64 | 72 | 23.9 | 3.19 | 6 | 24 | 1.567398119 | 2.5 | 3 | 6 | 28 | 16 | 12 | 9 | 37 | Post | 72 | 28 | 3.73 | 7 | 21 | 1.340482574 | 2.5 | 3 | 3 | 16 | 16 | |
6 | 5-PD | 0 | Pre | 56 | 2 | w | 0 | 60 | 140 | 27.3 | PD | 5 | 112 | 75 | 80 | 4.67 | 8 | 18 | 28 | 86 | 112 | 73 | 78 | 27.3 | 4.65 | 8 | 18 | 1.075268817 | 2.5 | 3 | 14 | 30 | 11 | 12 | 11 | 34 | Post | 112 | 29 | 5.13 | 8 | 18 | 0.974658869 | 2.5 | 3 | 20 | 10 | 11 | |
7 | 6-PD | 0 | Pre | 66 | 2 | w | 0 | 63 | 123 | 21.8 | PD | 7 | 139 | 83 | 66 | 4.11 | 6 | 24 | 25 | 106 | 139 | 83 | 66 | 21.8 | 4.23 | 6 | 24 | 1.182033097 | 2 | 3 | 2 | 27 | 15 | 10 | 10 | 35 | Post | 77 | 30 | 4.08 | 6 | 24 | 1.225490196 | 2.5 | 3 | 0 | 10 | 7 | |
8 | 7-PD | 1 | Pre | 66 | 1 | w | 0 | 61.1 | 197 | 27.5 | PD | 6 | 114 | 69 | 73 | 3.66 | 8 | 18 | 28 | 100 | 114 | 69 | 73 | 27.5 | 3.66 | 8 | 18 | 1.366120219 | 2 | 3 | 4 | 27 | 10 | 8 | 16 | 34 | Post | 100 | 28 | 3.7 | 6 | 24 | 1.351351351 | 1 | 3 | 2 | 12 | 12 | |
9 | 8-PD | 1 | Pre | 64 | 2 | w | 0 | 65 | 115 | 18.8 | PD | 4 | 128 | 70 | 72 | 3.68 | 6 | 24 | 28 | 88 | 128 | 70 | 72 | 18.8 | 4.4 | 7 | 21 | 1.136363636 | 2.5 | 3 | 6 | 30 | 12 | 8 | 14 | 34 | Post | 79 | 28 | 3.4 | 7 | 21 | 1.470588235 | 1 | 3 | 4 | 13 | 9 | |
10 | 9-PD | 0 | Pre | 56 | 1 | w | 0 | 75 | 275 | 34.4 | PD | 3 | 132 | 84 | 108 | 3.78 | 6 | 24 | 29 | 103 | 135 | 81 | 102 | 34.4 | 3.7 | 7 | 21 | 1.351351351 | 2 | 3 | 17 | 25 | 8 | 8 | 13 | 29 | Post | 97 | 29 | 3.6 | 7 | 21 | 1.388888889 | 2.5 | 3 | 20 | 10 | 9 | |
11 | 10-PD | 1 | Pre | 65 | 2 | w | 0 | 68 | 125 | 19 | PD | 4 | 147 | 98 | 90 | 6.03 | 11 | 13 | 28 | 79 | 124 | 80 | 75 | 19 | 4.89 | 9 | 16 | 1.022494888 | 4 | 3 | 20 | 29 | 14 | 15 | 13 | 42 | Post | 77 | 30 | 6.16 | 10 | 14 | 0.811688312 | 2.5 | 4 | 26 | 11 | 10 | |
12 | 11-PD | 1 | Pre | 60 | 1 | w | 0 | 77 | 229 | 28.2 | PD | 2 | 111 | 67 | 59 | 3.01 | 5.5 | 26 | 28 | 90 | 111 | 67 | 59 | 28.2 | 2.83 | 5 | 29 | 1.766784452 | 2.5 | 3 | 6 | 28 | 9 | 10 | 11 | 30 | Post | 95 | 27 | 6 | 24 | mv | 1.5 | 3 | 5 | 8 | 8 | ||
13 | 12-PD | 0 | Pre | 63 | 1 | w | 0 | 68 | 255 | 38.8 | PD | 8 | 138 | 87 | 67 | 5.11 | 7 | 21 | 24 | 81 | 138 | 87 | 67 | 38.8 | 4.38 | 6 | 24 | 1.141552511 | 3 | 3 | 16 | 23 | 9 | 11 | 14 | 34 | Post | 63 | 27 | 4.64 | 8 | 18 | 1.077586207 | 2 | 2 | 11 | 15 | 12 | |
14 | 13-PD | Excluded Adverse event | 1 | Pre | |||||||||||||||||||||||||||||||||||||||||||||
15 | 14-PD | 1 | Pre | 66 | 1 | w | 0 | 68 | 185 | 28.1 | PD | 10 | mv | mv | mv | 4.2 | 8 | 18 | 27 | 95 | mv | mv | mv | 28.1 | 4.43 | 8 | 18 | 1.128668172 | 2.5 | 3 | 7 | 28 | 16 | 9 | 18 | 43 | Post | 85 | 27 | 4.25 | 8 | 18 | 1.176470588 | 2.5 | 3 | 11 | 18 | 12 | |
16 | 1-MSA | 1 | Pre | 50 | 1 | w | 0 | MV | mv | mv | MSA | 2 | 104 | 68 | 59 | 3.11 | 5 | 29 | 27 | 97 | 104 | 68 | 59 | mv | 2.75 | 5 | 29 | 1.818181818 | 2.5 | 3 | 11 | 30 | 14 | 13 | 17 | 44 | Post | 94 | 27 | 2.99 | 5 | 29 | 1.672240803 | 2.5 | 3 | 12 | 16 | 12 |